ORADUR-hydrocodone

ORADUR-hydrocodone is an **extended-release oral formulation** of hydrocodone, a semi-synthetic opioid agonist derived from codeine, designed for around-the-clock management of severe chronic pain in opioid-tolerant patients when alternative treatments are inadequate. It binds primarily to **mu-opioid receptors** (MOR) in the central nervous system, with lesser affinity for delta (DOR) and kappa receptors, producing analgesia by activating inward rectifier potassium channels, inhibiting voltage-gated calcium channels, and reducing adenylyl cyclase activity, while also suppressing cough as an antitussive. Developed using **ORADUR technology**—a proprietary osmotic-controlled release system—this single-entity hydrocodone product aims to minimize abuse potential through resistance to crushing, chewing, or dissolution, though specific developer details are limited and it targets moderate-to-severe pain unresponsive to non-opioids.[7][10]

Brand names

ORADUR-hydrocodone