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ORAI1 inhibitor (Dongkwang)

Development stage: Preclinical
Lead developer: Dongkwang Pharm
Modality: Small Molecules
Administration: Topical

Overview

This herbal-based ORAI1 inhibitor is a natural product-derived therapeutic candidate being developed by Dongkwang for the treatment of atopic dermatitis. The drug's mechanism of action involves the inhibition of the ORAI1 ion channel, which is a key component of the store-operated calcium entry (SOCE) pathway. By blocking ORAI1, the drug aims to modulate calcium signaling in immune cells, thereby suppressing the production of pro-inflammatory cytokines and reducing the allergic inflammation characteristic of atopic dermatitis. The development of this compound was supported as a South Korean government research project from 2018 to 2022 and is currently in the preclinical stage.

Other names: ORAI1 inhibitor (herbal-based)Dongkwang ORAI1 inhibitor

Targets

ORAI1 (Calcium release–activated calcium channel protein 1)

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