oral enteric insulin

Oral enteric insulin is a specialized formulation of human insulin designed for oral administration, utilizing an enteric-coating technology to bypass gastric degradation. The formulation typically consists of insulin encapsulated within a delivery system, such as soft capsules, that remains intact in the acidic environment of the stomach and releases the active peptide upon reaching the higher pH of the small intestine. This approach aims to facilitate the absorption of insulin into the portal circulation, thereby mimicking the physiological secretion of endogenous insulin from the pancreas and potentially reducing the risk of peripheral hyperinsulinemia associated with subcutaneous injections. The specific formulation developed and studied by the West China Hospital of Sichuan University has undergone clinical evaluation to characterize its pharmacodynamic profile and relative bio-potency compared to traditional subcutaneous insulin therapies like NPH insulin.

Other names

oral insulin enteric-coated soft capsulesenteric-coated oral insulin