oral poliomyelitis vaccine

**Oral poliomyelitis vaccine** is a nonspecific category of live, attenuated poliovirus vaccines administered orally to prevent poliomyelitis. Conventional oral poliovirus vaccine is based on attenuated Sabin poliovirus strains and can be supplied as monovalent, bivalent, or trivalent products; the comparator described in the provided Phase 2 Sabin-IPV study was trivalent OPV containing Sabin poliovirus types 1, 2, and 3. Replication of attenuated vaccine virus in the intestinal tract induces serum neutralizing antibodies and intestinal mucosal immunity against poliovirus, helping interrupt transmission. Live OPV has been central to global polio-control programs but can rarely cause vaccine-associated paralytic poliomyelitis or generate vaccine-derived polioviruses through genetic reversion. ([who.int](https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/norms-and-standards/vaccine-standardization/poliomyelitis))

Other names

OPVoral polio vaccineoral poliovirus vaccine