Drug intelligence / Profile preview

oral rehydration salts

Development stage
Unknown
Lead developer
PUMC Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Oral rehydration salts (ORS) produced by PUMC Pharmaceutical is an approved electrolyte and glucose formulation designed for the treatment and prevention of dehydration caused by acute diarrhea and gastroenteritis. The therapy leverages the sodium-glucose cotransport mechanism in the small intestine; the presence of glucose facilitates the active transport of sodium ions across the intestinal epithelium via the SGLT1 transporter, which in turn creates an osmotic gradient that promotes the passive absorption of water. This formulation is essential in managing fluid loss and electrolyte imbalances, particularly in pediatric and geriatric populations, and is a cornerstone of gastroenterology management for diarrheal diseases.

Brand names
Oraline
Other names
ORSOral Rehydration Solution口服补液盐
02

Targets

SLC5A1 (Sodium Glucose Cotransporter 1)

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