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ORB-SF

Development stage: Preclinical
Lead developer: Theradaptive
Modality: Tissue Cells → Other Cell Types → Cell Therapies, Recombinant Proteins and Enzymes
Administration: Implant

Overview

**ORB-SF** is Theradaptive's preclinical spinal-fusion bone-graft product comprising its proprietary AMP2 protein immobilized on a ReBOSSIS synthetic scaffold. AMP2 is an engineered, device-binding variant of recombinant human bone morphogenetic protein 2 designed to remain localized at the implant surface, enabling controlled osteogenic signaling and bone formation at the fusion site. The product was listed for posterolateral spinal fusion.

Other names: AMP2 on ReBOSSISAMP-2 on ReBOSSISAMP 2 on ReBOSSISAMP2-coated ReBOSSISAMP-2-coated ReBOSSISAMP 2-coated ReBOSSISReBOSSIS + AMP2

Targets

BMPR1AACVR2A (Activin receptor type 2A)BMPR1BBMPR2 (Bone morphogenetic protein receptor type II)

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