Drug intelligence / Profile preview

ORBCEL-M

Development stage: Phase 2
Lead developer: Orbsen Therapeutics
Modality: Stem Cell Therapies → Cell Therapies
Administration: Intravenous

Overview

**ORBCEL-M** is an investigational, off-the-shelf allogeneic mesenchymal stromal cell therapy derived from healthy human bone marrow. The product is enriched by anti-CD362 antibody selection to yield an immunomodulatory stromal-cell population and is administered as a single intravenous infusion. It was developed by Orbsen Therapeutics for progressive diabetic kidney disease in adults with type 2 diabetes and evaluated in the randomized, placebo-controlled Phase 1b/2a NEPHSTROM study. Its intended therapeutic activity is pleiotropic rather than mediated through one defined drug target: the selected MSCs are intended to modulate maladaptive inflammatory and immune processes associated with diabetic kidney disease and may support renal protection. ([diabetestrialsctn.ie](https://diabetestrialsctn.ie/wp-content/uploads/2023/10/NEPHSTROM-paper.pdf))

Brand names: ORBCEL-M
Other names: Orbcel-MORBCEL-M cell

Beyond the preview

Go deeper on ORBCEL-M.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on ORBCEL-M.

Explore the full profile