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orbitazine fumarate
- Development stage
- Phase 2
- Lead developer
- Shenzhen Zhenxing Pharmaceutical Technology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Orbitazine fumarate (ZX-101) is a novel small-molecule tubulin inhibitor developed by Shenzhen Zhenxing Pharmaceutical Technology Co., Ltd. for the treatment of high-grade gliomas, including glioblastoma multiforme. It exerts its therapeutic effect by binding to the colchicine-binding site on tubulin, which inhibits microtubule polymerization and disrupts the formation of the mitotic spindle. This disruption leads to cell cycle arrest at the G2/M phase and induces apoptosis in rapidly proliferating tumor cells. Orbitazine is specifically designed to possess high blood-brain barrier permeability, addressing a major challenge in the treatment of primary central nervous system malignancies. It is currently being evaluated in clinical trials for patients with recurrent or refractory glioma.
- Other names
- orbitazine
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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