oren-to

Oren-to is a traditional Japanese Kampo medicine (herbal formula) composed of seven medicinal herbs: Coptis Rhizome, Glycyrrhiza, Ginger, Jujube, Ginseng, Cinnamon Bark, and Pinellia Tuber. It is traditionally indicated for the treatment of inflammatory conditions of the gastrointestinal tract, including stomatitis, gastritis, and vomiting. In modern clinical research, particularly in Japan, it is being investigated for its potential to prevent or mitigate the severity of radiation-induced oral mucositis in patients undergoing treatment for head and neck cancer. The formula's therapeutic effects are attributed to its complex polypharmacology, which includes anti-inflammatory and cytoprotective actions. Key active constituents, such as berberine from Coptis Rhizome and glycyrrhizin from Glycyrrhiza, are thought to inhibit the production of pro-inflammatory cytokines like TNF-alpha and IL-6, thereby protecting the mucosal lining from oxidative and inflammatory damage.

Brand names

Tsumura Orento Extract Granules

Other names

OrentoHuang-Lian-Tang