Drug intelligence / Profile preview

origanum syriacum extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Origanum syriacum extract is a plant-derived (botanical or herbal) extract prepared from the leaves or aerial parts of Origanum syriacum L., a shrubby medicinal plant native to the Mediterranean region and widely used in traditional medicine. The extract is a complex mixture of phytochemicals, rich in bioactive compounds such as carvacrol, thymol, flavonoids, and phenols, which contribute to its potent antioxidant, anti-inflammatory, and antimicrobial properties. In preclinical research, various preparations of the extract (including aqueous, ethanolic, and methanolic extracts) have demonstrated antiproliferative, apoptotic, and anti-angiogenic activities against breast cancer (specifically triple-negative breast cancer cells) and leukemia. It has also shown amoebicidal activity against Acanthamoeba castellanii and antibacterial efficacy against multidrug-resistant wound pathogens. Furthermore, in animal models of polycystic ovary syndrome (PCOS), the extract has been shown to alleviate depressive-like phenotypes, reduce neuroinflammation, reverse hyperandrogenism, and improve ovarian cysts by modulating the neuroendocrine-inflammatory axis. There is currently no single active pharmaceutical ingredient or defined biological target, and no commercial developer has been identified.

Other names
O. syriacum extractOriganum syriacum L. extractOriganum syriacum aqueous extractOriganum syriacum ethanolic extractOriganum syriacum methanolic extractOSEOSEE

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