ornidazole + ofloxacin + terbinafine + clobetasol

A fixed-dose topical combination drug containing four active agents: **ornidazole** (a nitroimidazole antimicrobial), **ofloxacin** (a fluoroquinolone antibiotic), **terbinafine** (an allylamine antifungal), and **clobetasol** (a potent corticosteroid). This combination is primarily used to treat mixed skin infections involving both bacteria and fungi, including dermatophyte infections (tinea corporis, tinea cruris, and tinea pedis), and for inflammatory skin conditions such as eczema or dermatitis complicated by secondary bacterial infection. - **Ornidazole** damages DNA in anaerobic bacteria and protozoa, leading to cell death. - **Ofloxacin** inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and leading to bactericidal activity against susceptible bacteria. - **Terbinafine** inhibits squalene epoxidase, leading to accumulation of squalene and disruption of fungal cell membranes, exerting fungicidal effects. - **Clobetasol** is a high-potency topical corticosteroid that reduces inflammation, edema, and erythema by suppressing various inflammatory mediators and immune cell activity. This combination is only for topical use on the skin and is not suitable for viral skin infections or for use on mucous membranes. It is generally considered for short-term use due to potential adverse effects, particularly from the corticosteroid component[1][3][7].

Other names

terbinafine + clobetasol + ofloxacin + ornidazole