Drug intelligence / Profile preview

Oroxylum indicum leaf extract

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Oroxylum indicum leaf extract is a natural product derived from the leaves of the Oroxylum indicum plant, a tree native to the Indian subcontinent and Southeast Asia. Historically, various parts of the Oroxylum indicum tree, including its leaves, have been extensively used in traditional Ayurvedic and Southeast Asian medicine for a wide array of ailments. The extract is rich in various phytochemicals, predominantly flavonoids such as baicalein, chrysin, and oroxylin A, along with phenols, tannins, and glycosides. These compounds are believed to be responsible for its diverse pharmacological activities, which include antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Research indicates that the extract can modulate cellular processes, such as inhibiting cancer cell proliferation, inducing apoptosis, and arresting the cell cycle. It is also studied for its hepatoprotective, immunomodulatory, and antidiabetic effects.

Other names
Shyonak leaf extractSonapatha leaf extractIndian trumpet tree leaf extractBroken bones tree leaf extractScythe tree leaf extractTree of Damocles leaf extractMidnight horror leaf extract
02

Targets

PGN (Peptidoglycan)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))NF-κBNOS2 (Nitric Oxide Synthase 2)

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