orphenadrine + acetaminophen + caffeine + diclofenac sodium

This is a fixed-dose combination drug containing orphenadrine, acetaminophen, caffeine, and diclofenac sodium. The formulation is designed to provide synergistic effects for the management of acute musculoskeletal pain and inflammation. - **Orphenadrine** is a centrally acting muscle relaxant with anticholinergic properties that helps relieve muscle spasm and associated pain. - **Acetaminophen** (paracetamol) acts as an analgesic and antipyretic by inhibiting prostaglandin synthesis in the central nervous system. - **Caffeine** serves as a central nervous system stimulant and can enhance the analgesic effect of other components. - **Diclofenac sodium** is a nonsteroidal anti-inflammatory drug (NSAID) that provides anti-inflammatory, analgesic, and antipyretic effects primarily through inhibition of cyclooxygenase enzymes COX-1 and COX-2[5]. The primary indication for this combination is the treatment of acute painful musculoskeletal conditions such as postural low back pain[5]. The rationale behind combining these agents is to achieve comprehensive relief by targeting different mechanisms involved in pain perception, inflammation, and muscle spasm.

Brand names

Tandrilax

Other names

orphenadrine + acetaminophen + caffeine + diclofenac sodiumorphenadrine citrate + acetaminophen + caffeine + diclofenac sodium