Drug intelligence / Profile preview

Orsiro

Development stage
Unknown
Lead developer
Biotronik
Modality
Small Molecules, Device-based Delivery → Drug Delivery Systems
Administration
Intracoronary
01

Overview

Orsiro is an ultra-thin strut, sirolimus-eluting coronary stent system developed for the treatment of coronary artery disease. It features a unique hybrid design that combines a passive proBIO coating, which encapsulates the cobalt-chromium metal stent to minimize ion release, and an active BIOlute biodegradable polymer coating. The BIOlute coating provides a controlled release of the antiproliferative drug sirolimus, which inhibits neointimal hyperplasia to prevent restenosis. The biodegradable polymer is designed to be fully resorbed within 12 to 24 months, eventually leaving behind a biocompatible bare metal stent. Orsiro has demonstrated clinical efficacy and safety across a broad range of patient populations, including those with stable angina and acute coronary syndromes such as ST-segment elevation myocardial infarction (STEMI).

Brand names
OrsiroOrsiro Mission
Other names
Orsiro SESOrsiro Sirolimus-eluting StentOrsiro Sirolimus-Eluting Coronary Stent System
02

Targets

Mechanistic target of rapamycin complex 1

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