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**Orthocann** is an investigational intra-articular cannabinoid-based nanoemulsion developed by Cannabis Bioscience International for knee osteoarthritis. The company describes the injection as containing its proprietary cannabinoids together with unspecified endogenous compounds, with the intended purpose of improving joint lubrication and potentially slowing cartilage damage; these effects remain investigational and have not been established in controlled published studies. The individual active constituents, direct molecular targets, and target-level mechanism of action have not been publicly disclosed. ([otcmarkets.com](https://www.otcmarkets.com/stock/CBIH/news/CBIH-Commences-Clinical-Trials-of-Osteoarthritis-Injection-Orthocann?id=433810))
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