Drug intelligence / Profile preview

orthosiphonis folium extract

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Orthosiphonis folium extract is a standardized herbal preparation derived from the dried leaves and stem tips of *Orthosiphon stamineus* (also known as *Orthosiphon aristatus*). Recognized in the European Pharmacopoeia, the extract contains a complex mixture of active constituents, including lipophilic flavones such as sinensetin, eupatorin, and scutellarein, as well as rosmarinic acid and various triterpenes. It is primarily utilized for its diuretic, anti-inflammatory, and antimicrobial properties, specifically for the irrigation of the urinary tract in cases of bacterial infections, inflammatory diseases, and kidney gravel. The diuretic mechanism involves enhanced ion excretion, which has been compared to the action of loop diuretics like furosemide. Beyond its primary urological indications, traditional uses include the management of hypertension, diabetes, and hyperlipidemia.

Brand names
Java teaCat's beard
Other names
Orthosiphon stamineus leaf extractOrthosiphon aristatus leaf extractFolium OrthosiphonisJava tea extractCat's whiskers extractCat's beard extract
02

Targets

COXADORA1 (Adenosine receptor A1 subtype)

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