Drug intelligence / Profile preview

osmanthus fragrans ethanol extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Inhalation, Topical, Sublingual
01

Overview

**Osmanthus fragrans ethanol extract** is a non-commercial botanical extract prepared from the flowers of *Osmanthus fragrans*, typically using approximately 75% to 80% ethanol extraction followed by concentration. It is best characterized as an academic preclinical research substance rather than a marketed therapeutic product. Reported bioactive constituents include phenylethanoid glycosides, phenolic acids, flavonoids, tannins, and related antioxidant phytochemicals. In experimental systems, the extract has shown antioxidant, anti-inflammatory, anti-allergic, anti-osteoclastogenic, and antiproliferative effects. Proposed mechanisms are pathway-level rather than a single defined drug-target interaction and include suppression of ovalbumin-specific immunoglobulin E production, reduction of inflammatory cell infiltration, activation of nuclear factor erythroid 2-related factor 2 mediated antioxidant responses, inhibition of nuclear factor kappa B signaling, and inhibition of osteoclast differentiation. Published work has explored potential relevance in allergic airway inflammation, asthma, oxidative stress-related disorders, periodontal disease, osteoporosis, pigmentation disorders, and prostate cancer cell models, but there is no clear evidence of formal clinical development, regulatory approval, or an identified commercial developer.

Other names
osmanthus fragrans ethanol extractOsmanthus fragrans flower ethanol extractOsmanthus fragrans extract
02

Targets

NF-κBNFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)

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