OSMI-4b

OSMI-4b is a potent, selective small molecule inhibitor of the enzyme O-linked N-acetylglucosamine transferase (OGT). It has an EC50 of approximately 3 μM in cells and is considered one of the most effective cell-active inhibitors for probing the biological functions of OGT. By inhibiting OGT, it reduces protein O-GlcNAcylation—a post-translational modification involved in numerous cellular processes including signaling, transcription regulation, and stress response. The compound was discovered through high-throughput screening and further optimized for potency. While highly useful as a research tool to study epigenetics and cell signaling pathways involving protein glycosylation, its physicochemical properties currently limit its development as a therapeutic drug candidate[1][3][5].

Other names

OGT inhibitor 4bOSMI 4OSMI4OSMI-4