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OST-tADC-FRA-H
- Development stage
- Preclinical
- Lead developer
- OS Therapies
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
OST-tADC-FRA-H is an experimental antibody-drug conjugate (ADC) developed by OncoSignature. It is designed to target Folate Receptor Alpha (FRα), a cell-surface protein that is highly expressed in various solid tumors, including ovarian, lung, and breast cancers, while having limited expression in normal tissues. The therapeutic strategy involves the specific binding of the antibody component to FRα-expressing cancer cells, followed by internalization of the ADC and subsequent release of a potent cytotoxic payload. This targeted delivery mechanism is intended to maximize anti-tumor activity while minimizing systemic toxicity. The 'H' in the designation likely refers to a humanized version of the antibody component, aimed at reducing immunogenicity in patients.
- Other names
- Tunable Antibody-drug conjugate -OS Therapeutics
02
Targets
FOLR1 (FRα)
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