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OsteoDex
- Development stage
- Phase 2
- Lead developer
- Dextech Solutions
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
**OsteoDex** is an investigational, bone-targeted polybisphosphonate polymer conjugate developed by DexTech Medical for cancer involving the skeleton, principally metastatic castration-resistant prostate cancer and relapsed or refractory multiple myeloma. It consists of a dextran carbohydrate backbone bearing covalently coupled alendronate and guanidine moieties. The alendronate-containing bisphosphonate component promotes accumulation at mineralized bone surfaces, while the agent inhibits osteoclast-mediated bone resorption and has reported cytotoxic antitumor activity. Clinical development has included completed Phase II studies in metastatic castration-resistant prostate cancer with bone metastases and a Phase I/IIa study in relapsed or refractory multiple myeloma. ([dextechmedical.com](https://dextechmedical.com/en/clinical-research/candidate-medications/))
- Brand names
- OsteoDex
- Other names
- poly-alendronate dextran-guanidine conjugatealendronate/dextran/guanidine
02
Targets
FDPS (Farnesyl pyrophosphate synthase)
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