osteopontin neutralizing antibody

An osteopontin neutralizing antibody is a therapeutic monoclonal antibody designed to bind and neutralize osteopontin (OPN, also known as secreted phosphoprotein 1 or SPP1). Osteopontin is a multifunctional extracellular matrix glycophosphoprotein and cytokine that plays a critical role in bone remodeling, cell-mediated immunity, inflammation, fibrosis, and tumor progression. By blocking the interaction of osteopontin with its receptors, such as integrins (e.g., alpha-9-beta-1, alpha-4-beta-1) and CD44, these antibodies inhibit downstream signaling pathways that drive inflammatory cell infiltration, macrophage polarization, and tumor immune evasion. Preclinical and clinical studies have investigated osteopontin neutralizing antibodies for the treatment of rheumatoid arthritis, various cancers (including colorectal, pancreatic, and hepatocellular carcinoma), and acute kidney injury-associated neuroinflammation.

Other names

OPN neutralizing antibodyanti-OPN antibodyanti-SPP1 antibodyanti-SPP-1 antibodyanti-SPP 1 antibodyanti-osteopontin antibodyosteopontin blockade antibodyosteopontin neutralizing monoclonal antibody