Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
OSUAB-0284
- Development stage
- Preclinical
- Lead developer
- The Ohio State University
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
OSUAB-0284 is a novel, small-molecule bacterial topoisomerase inhibitor (NBTI) under preclinical development for the treatment of multidrug-resistant bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA) and Bacillus anthracis (anthrax). Developed by researchers at The Ohio State University, OSUAB-0284 acts by dual-targeting bacterial type II topoisomerases, specifically DNA gyrase and topoisomerase IV. It inhibits supercoiling by DNA gyrase and decatenation by topoisomerase IV with balanced potency, promoting the accumulation of single-strand DNA breaks. Due to its unique binding mechanism, OSUAB-0284 maintains activity against fluoroquinolone-resistant strains, making it a promising candidate for addressing antimicrobial resistance.
- Other names
- OSUAB 0284OSUAB0284OSUAB-0284
02
Targets
DNA gyraseTopo IV (Bacterial Topoisomerase IV)
Beyond the preview
Go deeper on OSUAB-0284.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on OSUAB-0284.