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OT-1xx series
- Development stage
- Preclinical
- Lead developer
- Pangea Botanica
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
The OT-1xx series is a group of small molecule Tropomyosin receptor kinase B (TrkB) receptor agonists under development by Pangea Botanica (also known as Pangea Bio). Positioned as a "fast follower" program to the company's lead candidate OT-003, the OT-1xx series is designed to activate the TrkB signaling pathway, mimicking the effects of brain-derived neurotrophic factor (BDNF). This mechanism is intended to promote neuronal survival, enhance synaptic plasticity, and support neuroregeneration. The program has demonstrated activity in various preclinical models of central nervous system (CNS) disorders, targeting conditions with high unmet medical needs.
- Other names
- OT-1xx fast follower seriesOT1xx fast follower seriesOT 1xx fast follower series
02
Targets
NTRK2 (Tropomyosin-related kinase receptor type B)
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