OTL388

OTL388 is an investigational small-molecule imaging agent being developed by On Target Laboratories as part of its targeted intraoperative imaging portfolio, with preclinical work supported by NIH Small Business Innovation Research (SBIR) funding. It is described as a program alongside other folate- and PSMA-targeted optical imaging agents such as OTL38 and OTL78, and is intended to be conjugated to a near-infrared dye to selectively accumulate in antigen-expressing tumors to facilitate real-time intraoperative visualization and more complete surgical resection. Detailed target, structure, and clinical-stage information for OTL388 has not yet been publicly disclosed, but it is characterized as a tumor-targeted fluorescent imaging agent for cancer surgery applications.