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OTSA101-DTPA-111In
- Development stage
- Discontinued
- Lead developer
- Oncotherapy Science
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
OTSA101-DTPA-111In is a radiopharmaceutical composed of a humanized monoclonal antibody (OTSA101) targeting Frizzled homolog 10 (FZD10), which is overexpressed in synovial sarcoma. The antibody is conjugated with the chelator DTPA and labeled with the radioisotope indium-111. It is used for diagnostic imaging to assess biodistribution and tumor uptake in patients with relapsed or refractory synovial sarcoma, often as part of a theranostic approach preceding therapeutic administration of yttrium-90-labeled OTSA101. The drug was developed by OncoTherapy Science and has been evaluated in phase I clinical trials[3][5][6][7][8][9].
- Other names
- Indium 111-radiolabelled OTSA 101Indium111-radiolabelled OTSA 101Indium-111-radiolabelled OTSA 101
02
Targets
FZD10 (Frizzled homolog 10 receptor)
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