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OTSGC-A24
- Development stage
- Phase 2
- Lead developer
- Oncotherapy Science
- Modality
- Vaccines & Immunotherapeutics, Peptides
- Administration
- Subcutaneous
01
Overview
OTSGC-A24 is a peptide-based cancer vaccine developed for the treatment of advanced gastric cancer, specifically in patients with the HLA-A*24:02 haplotype. It is a cocktail of peptides that target five tumor-specific antigens—FOXM1, DEPDC1, KIF20A, URLC10, and VEGFR1. The vaccine works by inducing cytotoxic T lymphocyte (CTL) responses against these antigens presented on tumor cells, thereby promoting immune-mediated tumor cell killing. Preclinical studies demonstrated that both siRNA-mediated downregulation and active vaccination targeting these molecules led to tumor regression. Clinical trials have shown that OTSGC-A24 is well tolerated and capable of inducing significant CTL responses in patients[1][4][5]. The drug is administered subcutaneously at a recommended dose of 1 mg per injection[5]. Development has included combination studies with other immunotherapeutic agents such as nivolumab and ipilimumab[6].
- Other names
- Peptide vaccine (gastric cancer)
02
Targets
DEPDC1 (DEP domain-containing protein 1)Forkhead box protein M1-derived peptide epitopesHLA-A*24 (Major histocompatibility complex class I molecule presenting MAGE-A4 peptide)KIF20A (Kinesin family member 20A)LY6K (Lymphocyte antigen 6 complex locus protein K)VEGFR-1 (Vascular endothelial growth factor receptor 1)FOXM1 (Forkhead box protein M1)URLC10/HLA-A*24:02 (URLC10 peptide-HLA-A*24:02 complex)
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