Drug intelligence / Profile preview

OTX-003

Development stage
Preclinical
Lead developer
OncoBone Ventures
Modality
Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
01

Overview

OTX-003 is a preclinical-stage radiopharmaceutical being developed by OncoBone Therapeutics for the treatment of bone metastatic castration-resistant prostate cancer (mCRPC) and other bone-metastasizing malignancies. The drug is developed using an osteoimmuno-oncology (OIO) approach, which focuses on the complex interactions between cancer cells, the bone microenvironment, and the immune system. OTX-003 is part of OncoBone's internal proprietary pipeline and is currently undergoing proof-of-concept studies. The company's business model involves advancing such assets to an IND-ready stage using their specialized Bone Metastasis Technology Platform before out-licensing to larger pharmaceutical partners for clinical trials.

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