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OV185

Development stage: Unknown
Lead developer: DPC Biermann
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

OV185 is a monoclonal antibody directed against the CA125 antigen (Mucin 16), a high-molecular-weight glycoprotein that is a well-established biomarker for ovarian cancer. It is primarily utilized as a diagnostic reagent, notably as the capture or detection antibody in the IMMULITE OM-MA chemiluminescent assay for the quantitative measurement of CA125 in human serum. Beyond its diagnostic applications, OV185 has been investigated in preclinical research for its tumor-targeting properties. Studies have evaluated its biokinetics and biodistribution when radiolabeled with isotopes such as Iodine-125 (125I) in human ovarian cancer xenograft models. It was also characterized in the International Society for Oncodevelopmental Biology and Medicine (ISOBM) TD-1 Workshop, where its immunohistochemical staining properties and epitope specificity were compared against other anti-CA125 antibodies like OC125 and M11.

Other names: Anti-CA125 monoclonal antibody OV185Anti-CA-125 monoclonal antibody OV185Anti-CA 125 monoclonal antibody OV185

Targets

MUC16 (Mucin-16)

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