ovalbumin peptide

**Ovalbumin peptide** refers to specific peptide fragments derived from ovalbumin, a protein found in egg white, frequently used as model antigens in immunology and biomedical research[1][2][3][5][7]. Two of the most widely studied ovalbumin peptides are SIINFEKL (OVA 257-264) and ISQAVHAAHAEINEAGR (OVA 323-339). These peptides are used to study antigen-specific T cell responses: - **SIINFEKL (257-264)** is a MHC class I-restricted (Kb) epitope recognized by CD8+ T cells, commonly used to model cytotoxic T cell responses[1][3][8]. - **ISQAVHAAHAEINEAGR (323-339)** is a MHC class II-restricted epitope recognized by CD4+ T cells, and is used to study T helper cell responses and allergic mechanisms[5]. Ovalbumin peptides can be administered alone or as part of vaccine formulations, with carriers (e.g., alginate nanoparticles) or adjuvants to induce strong immune responses, and have shown immunomodulatory effects, including tumor suppression in preclinical models[2][7]. They are also used experimentally in models of autoimmunity, allergy, and cancer immunotherapy due to their ability to induce robust, antigen-specific immune reactions in genetically defined animal strains[2][3][7].

Other names

OVA(257-264)OVA(323-339)SIINFEKLISQAVHAAHAEINEAGR