ovatodiolide

**Ovatodiolide** is a small molecule phytochemical isolated from *Anisomeles indica*. It is under investigation for its anti-inflammatory, anticancer, and antibacterial activity. Mechanistically, it inhibits key oncogenic signaling pathways including YAP1, NF-κB, Kras/MEK/ERK, mTOR, β-catenin, Notch1, and STAT3, and affects tumor microenvironment modifiers such as IL-6 and TGF-β1. Ovatodiolide suppresses cancer stem cell self-renewal and migration, and has been shown to reduce exosomal oncomiRs like miR-1246. In antibacterial settings, it targets the ribosomal protein RpsB, interfering with bacterial protein synthesis[1][3][4][7][14]. It is being evaluated for atopic dermatitis and experimental and preclinical models of colon cancer, endometrial cancer, and liver inflammation, with additional investigation in bacterial infections, including *Helicobacter pylori*[1][3][4][7][10][13][14].

Other names

(3as,6e,13s,15e,16ar)-3a,4,5,8,9,13,14,16a-octahydro-6,15-dimethyl-3-methylene-11h-13,10-methenofuro(2,3-f)oxacyclopentadecin-2,11(3h)-dione(3e,12e)-3,12-dimethyl-8-methylene-6,18-dioxa-tricyclo(14.2.1.0.5,9)nonadeca-3,12,16(19)-triene-7,17-dione(1S,3E,5R,9S,12E)-3,12-dimethyl-8-methylidene-6,18-dioxatricyclo[14.2.1.05,9]nonadeca-3,12,16(19)-triene-7,17-dione