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Ovral
- Development stage
- Preclinical
- Lead developer
- PAI Life Sciences
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
Ovral (also known as Ov-RAL-2) is a preclinical-stage recombinant protein subunit vaccine candidate being developed by Vaxine Pty Ltd under the VaxCelerate Consortium. The vaccine is designed to target the RAL-2 antigen of *Onchocerca volvulus* and the closely related cattle parasite *Onchocerca ochengi* to prevent onchocerciasis (river blindness), a debilitating neglected tropical disease. Formulated with Vaxine's proprietary Advax adjuvant platform (such as Advax-2 or Advax-CpG), Ovral aims to induce a robust, protective, and Th2-biased immune response characterized by high titers of antigen-specific IgG antibodies. This immune response facilitates the clearance of infective larvae, offering a potential prophylactic tool to support mass drug administration campaigns.
- Other names
- Onchocerca volvulus antigen RAL-2recombinant Onchocerca volvulus antigen RAL-2
02
Targets
Ov-103 (Onchocerca volvulus Ov-103 antigen)TLR9 (Toll-like receptor 9)Ov-RAL-2 (Onchocerca volvulus retinol-binding protein-like 2)
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