oxafuramine

Oxafuramine is a synthetic stimulant and anorectic drug belonging to the oxazoline chemical class. It is structurally related to aminorex and 4-methylaminorex. Developed in the 1960s, oxafuramine was investigated for its potential as an appetite suppressant. Its mechanism of action involves sympathomimetic activity, likely through the modulation of monoamine transporters, leading to increased levels of norepinephrine and dopamine in the synaptic cleft. Despite its pharmacological potential, oxafuramine was never approved for clinical use or widely marketed, and it remains primarily a compound of historical and toxicological interest.

Other names

2-amino-4-methyl-5-phenyl-2-oxazoline4-methyl-5-phenyl-4,5-dihydro-1,3-oxazol-2-amine