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oxaliplatin + raltitrexed + tislelizumab + surufatinib + TAE
- Development stage
- Phase 2
- Lead developer
- BeiGene
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intra-arterial, Intravenous, Oral
01
Overview
HAIC + TAE sequential therapy combined with tislelizumab and surufatinib is an investigational multi-modal treatment regimen for unresectable intrahepatic cholangiocarcinoma (iCCA). The regimen, currently being evaluated in the Phase II REACH-01 trial (NCT06239532) by Qilu Hospital of Shandong University, combines hepatic artery infusion chemotherapy (HAIC) using oxaliplatin and raltitrexed with transcatheter arterial embolization (TAE). This locoregional approach is supplemented by systemic therapy consisting of tislelizumab, a humanized IgG4 anti-PD-1 monoclonal antibody, and surufatinib, a small molecule inhibitor of VEGFR 1/2/3, FGFR1, and CSF-1R. The combination aims to leverage the synergistic effects of local tumor destruction, anti-angiogenesis, and immune checkpoint inhibition to improve outcomes in patients with advanced biliary tract cancers.
- Other names
- HAIC+TAE + Tislelizumab + SurufatinibHAIC sequential TAE combined with Tislelizumab and Surufatinib
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)DNAFGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)PDCD1 (Programmed cell death protein 1 receptor)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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