oxaloacetate + ascorbic acid

**Oxaloacetate + ascorbic acid** is a combination oral supplement composed of oxaloacetate (a metabolic intermediate involved in the citric acid cycle) and ascorbic acid (vitamin C), primarily developed to increase the stability and bioavailability of oxaloacetate for use in clinical applications. Oxaloacetate is known for its roles in glucose regulation, modulation of neurotransmitter balance (notably the GABA/glutamate ratio), and influence on metabolic and gene expression pathways. Ascorbic acid is included due to its capacity to improve oxaloacetate stability at room temperature, thereby enhancing the practical utility of the formulation. Clinical trials demonstrate this combination significantly improves emotional symptoms—such as depression, anxiety, perceived stress, aggression, and suicidal ideation—associated with premenstrual syndrome (PMS). Mechanistically, the enhanced stability of oxaloacetate allows it to exert biological effects potentially through both acute metabolic support and persistent gene expression modulation[1][3][6].

Other names

oxaloacetate/vitamin Coxaloacetic acid + vitamin C