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Drug intelligence / Profile preview
oxalomalic acid
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
Oxalomalic acid (also known as oxalomalate) is a small molecule tricarboxylic acid derivative that acts as a competitive inhibitor of aconitase and NADP-dependent isocitrate dehydrogenase (IDH). It is formed in vivo by the condensation of oxaloacetate with glyoxylate. By inhibiting aconitase, oxalomalic acid modulates the RNA-binding activity of iron-regulatory proteins (IRPs), leading to a decrease in IRP1 binding activity and a reduction in glutamate secretion. Additionally, it has been investigated in vitro and in silico as a potential therapeutic agent for prostate adenocarcinoma (PRAD) due to its ability to inhibit IDH1, which is often overexpressed in PRAD and associated with poor prognosis and immune cell infiltration. It is primarily utilized as a research-use-only laboratory reagent.
- Other names
- 3-oxalomalate3-oxalomalic acidoxalomalateoxalomalate trisodiumoxalomalic acid trisodium
02
Targets
IDH1 (Isocitrate dehydrogenase [NADP] cytoplasmic)IDH2 (Isocitrate dehydrogenase [NADP], mitochondrial (mutant))
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