oxeladin

Oxeladin is a non-narcotic, small molecule antitussive that acts as a selective sigma-1 receptor agonist. It centrally inhibits the cough reflex without the risks of dependence, respiratory depression, or sedation associated with opioid-based cough suppressants like codeine. While historically marketed under brand names such as Paxeladine and Tussoril for non-productive cough, it was withdrawn from several major markets, including the US and UK, in 1976 due to concerns regarding potential carcinogenicity. More recently, clinical research in China has explored its use as an adjunct in painless gastrointestinal endoscopy procedures, investigating its efficacy in managing procedure-related pain and its interaction with anesthetics like cyclopofol.

Brand names

TussorilPaxeladinePaxladineTuscalmanPectamolTussimol

Other names

oxeladin citrateoxelidine fumarateoxelidin2-(2-diethylaminoethoxy)ethyl 2-ethyl-2-phenyl-butanoate