oxidized nanocellulose gel

Oxidized nanocellulose gel is a hydrogel formulation derived from cellulose that has been chemically modified through oxidation processes—most commonly using TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) as a catalyst. This modification introduces carboxyl groups onto the cellulose backbone, enhancing its hydrophilicity and enabling the formation of stable three-dimensional networks in aqueous environments. The resulting gels exhibit high biocompatibility, tunable mechanical properties, and excellent water retention. Mechanism of action centers on providing a physical scaffold that mimics the extracellular matrix (ECM), supporting cell adhesion and proliferation while serving as a barrier or carrier for bioactive molecules. In biomedical applications—including wound healing and tissue engineering—the gel acts as an anti-adhesion barrier post-surgery or as a drug delivery vehicle with controlled release properties. Its surface chemistry allows for further functionalization to deliver drugs or cells in targeted therapies[5][6][8].

Other names

TEMPO-oxidized nanocellulose gelTOCN hydrogeloxidized cellulose nanofiber hydrogeloxidized CNF gel