Oxiplex

Oxiplex is an absorbable, viscoelastic hydrogel designed to serve as a temporary mechanical barrier to prevent the formation of postoperative adhesions following surgical procedures, particularly in the spine. Developed by FzioMed, the gel is composed of a proprietary formulation of carboxymethylcellulose (CMC) and polyethylene oxide (PEO). Its primary mechanism of action involves the physical separation of traumatized tissue surfaces and nerve roots during the critical healing period, thereby inhibiting the development of fibrotic scar tissue (adhesions) that can lead to failed back surgery syndrome and chronic pain. Oxiplex is applied topically to the surgical site before closure and is naturally cleared by the body through normal metabolic pathways. While it has received widespread regulatory approval internationally, including the CE Mark in Europe for indications such as lumbar laminectomy and radiculopathy, its path to FDA approval in the United States has involved extensive clinical review and regulatory challenges.

Brand names

OxiplexOxiplex/SPOxiplex/APOxiplex/IUMedishield

Other names

CMC/PEO gelFzioMed gelcarboxymethylcellulose/polyethylene oxide gel