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OXIRI
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
OXIRI is a chemotherapy regimen comprising oxaliplatin, capecitabine (Xeloda), and irinotecan. It is being investigated for the treatment of advanced and/or metastatic pancreatic adenocarcinoma and metastatic pancreatic cancer. The regimen is designed to be more tolerable than FOLFIRINOX, with chronomodulated capecitabine administration and UGT1A1 genotype-guided dosing of irinotecan. It has shown preliminary evidence of efficacy and immunomodulatory effects.
- Other names
- Low Dose OXIRImetronomic capecitabine + metronomic oxaliplatin + irinotecan
02
Targets
TOP1 (DNA Topoisomerase I)DNATS (Thymidylate synthase)
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