OXM14E3

OXM14E3 is an experimental peptide analogue of oxyntomodulin (OXM), a dual agonist of the glucagon-like peptide-1 (GLP-1) and glucagon receptors. It is a modified version of the analogue OXM14, featuring a glutamate (Glu) substitution at the third amino acid position (E3). This specific modification is designed to significantly reduce or abolish activity at the glucagon receptor while maintaining activity at the GLP-1 receptor. In preclinical rat models, OXM14E3 was used to demonstrate that the unexpected orexigenic (appetite-stimulating) effects of certain oxyntomodulin analogues like OXM14 were mediated through glucagon receptor activation, as OXM14E3 failed to increase food intake. It was primarily developed as a research tool to dissect the pharmacology of dual GLP-1/glucagon receptor agonism in the context of obesity and metabolic regulation.

Other names

Glu3-OXM14Glu-3-OXM14Glu 3-OXM14[Glu3]OXM14