OXM15E3

OXM15E3 is a synthetic, PEGylated peptide analogue of oxyntomodulin (OXM), specifically a modified version of the analogue OXM15. It features a glutamate (Glu) substitution at the third amino acid position (Glu-3), a structural modification designed to selectively reduce or eliminate its activity at the glucagon receptor (GCGR) while maintaining its potency as an agonist of the glucagon-like peptide-1 receptor (GLP-1R). Developed by researchers at Imperial College London, OXM15E3 was utilized in preclinical studies to investigate the mechanisms underlying the regulation of food intake. While the parent compound OXM15 was found to unexpectedly increase food intake in rat models, OXM15E3 did not produce this hyperphagic effect. This finding indicated that the paradoxical increase in food intake observed with certain oxyntomodulin analogues is mediated through glucagon receptor activation rather than GLP-1 receptor signaling.

Other names

[Glu3]OXM15Glu-3 OXM15Glu3 OXM15Glu 3 OXM15