oxomemazine

Oxomemazine is a first-generation phenothiazine derivative antihistamine primarily used for the treatment of allergies, pruritic skin disorders, and cough. It acts as a sedating antihistamine by competitively binding to the histamine H1 receptor, thereby inhibiting the pharmacological effects of histamines. In addition to its antihistaminic action, oxomemazine exhibits anticholinergic and antiserotoninergic properties, contributing to its sedative effects. Its clinical uses include relief from hypersensitivity reactions and allergic skin conditions such as urticaria. Oxomemazine is known for causing sedation due to its ability to cross the blood-brain barrier[1][2][4][5][6][7][8].