oxotremorine

Oxotremorine is a synthetic small molecule and a potent, non-selective muscarinic acetylcholine receptor (mAChR) agonist, acting on receptor subtypes M1 to M5. Primarily used as a research tool, oxotremorine induces signs of Parkinsonian-like tremor, ataxia, and spasticity in animal models, facilitating the investigation of anti-Parkinsonian and antipsychotic drug candidates. It crosses the blood-brain barrier and produces a range of central and peripheral cholinergic effects. Research in rodents has shown that oxotremorine can reduce repetitive behaviors associated with autism models and may have neuroprotective and antioxidant properties through modulation of both inflammatory and neurotrophic signaling pathways. Oxotremorine is not used therapeutically but is essential in preclinical neuroscience and pharmacological research[1][3][4][6][9][10].

Other names

oxotremorin2’-oxopyrrolidino-1-pyrrolidino-4-butyne1-(4-pyrrolidin-1-ylbut-2-ynyl)-2-pyrrolidone1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinon1-[4-(1-PYRROLIDINYL)-2-BUTYNYL]-2-PYRROLIDINONE1-(4-(pyrrolidin-1-yl)but-2-ynyl)pyrrolidin-2-one1-[4-(Pyrrolidin-1-yl)-2-butynyl]pyrrolidin-2-one1-(4-(Pyrrolidin-1-yl)but-2-yn-1-yl)pyrrolidin-2-one1-(2-Oxopyrrolidin-1-yl)-4-(pyrrolidin-1-yl)-2-butyne