oxygen-ozone gas mixture

Oxygen-ozone gas mixture is a medical gas therapy composed of a specific concentration of ozone (O3) in medical-grade oxygen (O2). Developed for clinical investigation by El Hospital Universitario De Gran Canaria Dr. Negrin, it is primarily being studied for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). The mixture acts as a mild, controlled oxidative stressor that triggers the activation of the Nrf2 (nuclear factor erythroid 2-related factor 2) signaling pathway, leading to the upregulation of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase. Additionally, it improves tissue oxygenation by increasing 2,3-diphosphoglycerate (2,3-DPG) levels in red blood cells, which shifts the hemoglobin-oxygen dissociation curve to the right, and modulates the release of anti-inflammatory cytokines. In patients with CIPN, these mechanisms are intended to reduce oxidative damage to peripheral nerves and improve microcirculatory blood flow, thereby alleviating neuropathic pain and sensory deficits.

Other names

medical ozoneozone-oxygen therapyO3-O2 mixtureO-3-O2 mixtureO 3-O2 mixtureozone therapy