oxymetazoline

Oxymetazoline is a direct-acting sympathomimetic and imidazole derivative that acts as a potent agonist at alpha-1A adrenergic receptor and alpha-2 adrenergic receptor. It is primarily used as a topical decongestant for the temporary relief of nasal congestion caused by colds or allergies and for the treatment of facial erythema associated with rosacea. Oxymetazoline is also used in ophthalmic preparations to relieve eye redness and in topical formulations to treat acquired blepharoptosis (drooping eyelid). Its mechanism involves vasoconstriction of dilated arterioles through stimulation of adrenergic receptors in vascular smooth muscle. This reduces blood flow and swelling in mucosal tissues. The drug provides rapid relief from congestion with effects lasting up to 12 hours after intranasal administration.

Brand names

AfrinDristan 12-hour Nasal SprayDristan12-hour Nasal SprayDristan-12-hour Nasal SprayKovanazeNostrillaRhofadeSinex Long-actingUpneeq4-Way Long LastingDuramist PlusDurationGenasalMucinex Full ForceMucinex Moisture SmartNasaconNasinNeo-Synephrine 12 HourNeo-Synephrine12 HourNeo-Synephrine-12 HourNRS-Nasal ReliefSinarest Nasal SprayVicks Sinex 12 HourZicam Sinus ReliefAfrin NoDrip Severe CongestionZicam Extreme Congestion ReliefAfrin OriginalOcuClear

Other names

oxymetazoline nasal sprayoxymetazoline