Drug intelligence / Profile preview

oxytetracycline + cyclophosphamide

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral, Intravenous (for Cyclophosphamide), Topical (for Oxytetracycline In Some Formulations)
01

Overview

Oxytetracycline + cyclophosphamide is a combination of two pharmaceutical agents with distinct mechanisms of action. Oxytetracycline is a broad-spectrum tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to growing peptide chains. It is primarily used for treating infections caused by Gram-positive and Gram-negative bacteria[5]. Cyclophosphamide is an alkylating agent used as chemotherapy and immunosuppressant; it requires hepatic activation to form active metabolites that crosslink DNA, leading to cell death. Cyclophosphamide is indicated for various cancers (including lymphomas, leukemias, breast cancer) and some autoimmune diseases[8][10]. There are no widely recognized or approved clinical uses for this specific combination; each drug has established indications individually.

Other names
oxytetracycline and cyclophosphamideoxytetracycline plus cyclophosphamide
02

Targets

Bacterial RibosomeDNA

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