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Pílulas de Lussen

Development stage: Phase 3
Lead developer: Laboratórios Osório De Moraes
Modality: Small Molecules
Administration: Oral

Overview

Pílulas de Lussen is a traditional Brazilian oral combination therapy developed by Laboratórios Osório De Moraes for the symptomatic relief of dysuria and urinary tract discomfort. The formulation typically contains methylene blue and acriflavine hydrochloride, which function as urinary antiseptics. Methylene blue acts as a mild antiseptic and redox agent, while acriflavine is a topical and urinary antiseptic known to intercalate into microbial DNA. The drug has been evaluated in Phase III clinical trials (such as NCT01441011) to assess its efficacy and safety compared to phenazopyridine (Pyridium) for the control of painful urination in adults.

Brand names: Pílulas de Lussen

Targets

PDE (Phosphodiesterase family)ADOR (Adenosine receptors)mAChR (Muscarinic acetylcholine receptors)

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