P-113D

P-113D is a novel 12-amino acid antimicrobial peptide drug derived from histatins, which are naturally occurring compounds in human saliva. It is a D-enantiomeric form of the peptide sequence AKRHHGYKRKFH and was developed to be resistant to enzymatic degradation while retaining potent antimicrobial activity. P-113D acts by binding to microbial cell surfaces and increasing membrane permeability, leading to rapid cell death in both Gram-negative and Gram-positive bacteria as well as fungi such as Candida albicans. The drug has demonstrated significant activity against clinical isolates from cystic fibrosis (CF) patients that are resistant to traditional antibiotics and remains active in CF sputum. Its primary indication under investigation is for the treatment of cystic fibrosis-related infections[1][2][3][4].

Brand names

Pulmadex

Other names

D-peptide of the sequence AKRHHGYKRKFH-NH2P-113dP113dP 113dhistatin 5 derivativehistatin5 derivativehistatin-5 derivative