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P-Esbp-DOX
- Development stage
- Preclinical
- Lead developer
- Vaxil Bio
- Modality
- Small Molecules, Peptides, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
P-Esbp-DOX is a preclinical **E-selectin-targeted HPMA polymer-doxorubicin conjugate** developed from research at Ben-Gurion University of the Negev and licensed to Vaxil Bio. The construct displays a high-affinity E-selectin-binding peptide on an N-(2-hydroxypropyl)methacrylamide polymer carrier and carries covalently conjugated doxorubicin. It is designed to bind activated, inflamed and angiogenic tumor endothelium expressing E-selectin, promote endothelial uptake and local delivery of doxorubicin, thereby impairing tumor-associated vasculature and suppressing metastatic tumor growth. In mouse studies, intravenous P-Esbp-DOX improved survival and reduced metastatic burden in colorectal cancer liver metastasis and lung cancer metastasis models.
- Other names
- P-(Esbp)-DOXP-ESBP-DOX
02
Targets
SELE (E-selectin)TOP2A (DNA topoisomerase II)DNA
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