P. acnes Avidocin

P. acnes Avidocin is a preclinical therapeutic protein candidate developed by Pylum Biosciences for the treatment of acne. It belongs to a class of engineered R-type pyocins known as Avidocins, which are high-molecular-weight, contractile protein complexes derived from bacteriocins. The mechanism of action involves the highly specific recognition of surface receptors on *Cutibacterium acnes* (formerly *Propionibacterium acnes*), followed by the contraction of the protein sheath to punch a hole through the bacterial cell envelope. This results in rapid membrane depolarization and bacterial death. Unlike broad-spectrum antibiotics, P. acnes Avidocin is designed to be highly specific, potentially reducing the risk of antibiotic resistance and minimizing disruption to the commensal skin microbiome.

Other names

Cutibacterium acnes AvidocinPropionibacterium acnes AvidocinAvidocin-Acne